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3. The Scientific Steering Committee’s five examples of diseases of concern

Posted: 13 July 2007

(c) Tuberculosis

SSC: “A careful analysis of two macaque models (rhesus and cynomologus) has shown the value of these two models and their similarity to the human situation”.
“These models are being used to screen and select among new candidate vaccines”.

ADI Response:

• Research examining the use of two primate species to test the efficacy of TB vaccine bacillus Calmette-Guerin (BCG), found that they differed greatly in the efficacy of BCG53.
• One study of the early stages of TB in primates stated that “like human studies, the genetic diversity of monkeys results in an inherent degree of animal-to-animal variability and, therefore, heterogeneity of data is seen”54.
• A study of the effects of TB on animals showed that they had widely disparate pathogenicities. This led to the conclusion that “the outbred nature of macaques can be viewed as a limitation on performing some studies”55.

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